IL-23/IL-17 Axis in IBD

被引：226

作者：

Sarra, Massimiliano ^{[1
]}

Pallone, Francesco ^{[1
]}

MacDonald, Thomas T. ^{[2
]}

Monteleone, Giovanni ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dipartimento Med Interna, Cattedra Gastroenterol, I-00133 Rome, Italy

[2] Barts & London Queen Marys Sch Med & Dent, Inst Cell & Mol Sci, London, England

来源：

INFLAMMATORY BOWEL DISEASES | 2010年 / 16卷 / 10期

关键词：

Th17; IL-17; IL-23; IL-21; IBD; INFLAMMATORY-BOWEL-DISEASE; ACTIVE CROHNS-DISEASE; MEDIATED INTESTINAL INFLAMMATION; CELL-DEPENDENT COLITIS; HUMAN TH17 CELLS; T-HELPER-CELLS; ULCERATIVE-COLITIS; AUTOIMMUNE ENCEPHALOMYELITIS; ROR-GAMMA; TGF-BETA;

D O I：

10.1002/ibd.21248

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Gut inflammation occurring in patients with Crohn's disease and patients with ulcerative colitis has been traditionally associated with an exaggerated Th1 or Th2 cell response, respectively. However, recent studies have shown that in both inflammatory bowel diseases (IBD) there is also enhanced synthesis of cytokines made by a distinct subset of T helper cells, termed Th17 cells. The discovery that this new T-cell subset drives immune-mediated pathology in the gut, and that interleukin (IL)-23 amplifies Th17 cell responses and gut inflammation, has contributed to elucidate new pathways of tissue damage as well as to open new avenues for development of therapeutic strategies in IBD. Nonetheless, it has been recently shown that Th17-related cytokines, such as IL-17A and IL-22, can exert protective rather than detrimental effects in the gut. We here review the available data regarding the role of Th17 cells and IL-23 in chronic intestinal inflammation. (Inflamm Bowel Dis 2010; 16: 1808-1813)

引用

页码：1808 / 1813

页数：6

共 66 条

[41] Interleukin-17 family and IL-17 receptors [J].

Moseley, TA ;

Haudenschild, DR ;

Rose, L ;

Reddi, AH .

CYTOKINE & GROWTH FACTOR REVIEWS, 2003, 14 (02) :155-174

[42] The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease [J].

Neurath, MF ;

Weigmann, B ;

Finotto, S ;

Glickman, J ;

Nieuwenhuis, E ;

Iijima, H ;

Mizoguchi, A ;

Mizoguchi, E ;

Mudter, J ;

Galle, PR ;

Bhan, A ;

Autschbach, F ;

Sullivan, BM ;

Szabo, SJ ;

Glimcher, LH ;

Blumberg, RS .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (09) :1129-1143

[43] Blocking of IL-6 signaling pathway prevents CD4+ T cell-mediated colitis in a Th17-independent manner [J].

Noguchi, Daisuke ;

Wakita, Daiko ;

Tajima, Masaki ;

Ashino, Shigeru ;

Iwakura, Yoichiro ;

Zhang, Yue ;

Chamoto, Kenji ;

Kitamura, Hidemitsu ;

Nishimura, Takashi .

INTERNATIONAL IMMUNOLOGY, 2007, 19 (12) :1431-1440

[44] Essential autocrine regulation by IL-21 in the generation of inflammatory T cells [J].

Nurieva, Roza ;

Yang, Xuexian O. ;

Martinez, Gustavo ;

Zhang, Yongliang ;

Panopoulos, Athanasia D. ;

Ma, Li ;

Schluns, Kimberly ;

Tian, Qiang ;

Watowich, Stephanie S. ;

Jetten, Anton M. ;

Dong, Chen .

NATURE, 2007, 448 (7152) :480-U8

[45] Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis [J].

O'Connor, Richard A. ;

Prendergast, Catriona T. ;

Sabatos, Catherine A. ;

Lau, Clement W. Z. ;

Leech, Melanie D. ;

Wraith, David C. ;

Anderton, Stephen M. .

JOURNAL OF IMMUNOLOGY, 2008, 181 (06) :3750-3754

[46] A protective function for interleukin 17A in T cell-mediated intestinal inflammation [J].

O'Connor, William, Jr. ;

Kamanaka, Masahito ;

Booth, Carmen J. ;

Town, Terrence ;

Nakae, Susumu ;

Iwakura, Yoichiro ;

Kolls, Jay K. ;

Flavell, Richard A. .

NATURE IMMUNOLOGY, 2009, 10 (06) :603-U65

[47] Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 [J].

Oppmann, B ;

Lesley, R ;

Blom, B ;

Timans, JC ;

Xu, YM ;

Hunte, B ;

Vega, F ;

Yu, N ;

Wang, J ;

Singh, K ;

Zonin, F ;

Vaisberg, E ;

Churakova, T ;

Liu, MR ;

Gorman, D ;

Wagner, J ;

Zurawski, S ;

Liu, YJ ;

Abrams, JS ;

Moore, KW ;

Rennick, D ;

de Waal-Malefyt, R ;

Hannum, C ;

Bazan, JF ;

Kastelein, RA .

IMMUNITY, 2000, 13 (05) :715-725

[48] The biological functions of T helper 17 cell effector cytokines in inflammation [J].

Ouyang, Wenjun ;

Kolls, Jay K. ;

Zheng, Yan .

IMMUNITY, 2008, 28 (04) :454-467

[49] IFN-β Inhibits Human Th17 Cell Differentiation [J].

Ramgolam, Vinod S. ;

Sha, Yonggang ;

Jin, Jianping ;

Zhang, Xin ;

Markovic-Plese, Silva .

JOURNAL OF IMMUNOLOGY, 2009, 183 (08) :5418-5427

[50] Differential regulation of interleukin 17 and interferon γ production in inflammatory bowel disease [J].

Rovedatti, L. ;

Kudo, T. ;

Biancheri, P. ;

Sarra, M. ;

Knowles, C. H. ;

Rampton, D. S. ;

Corazza, G. R. ;

Monteleone, G. ;

Di Sabatino, A. ;

MacDonald, T. T. .

GUT, 2009, 58 (12) :1629-1636

← 1 2 3 4 5 6 7 →