An efficient palladium catalyzed synthesis of 2-arylbenzothiazoles

被引：73

作者：

Majo, VJ ^{[1
]}

Prabhakaran, J ^{[1
]}

Mann, JJ ^{[1
]}

Kumar, JSD ^{[1
]}

机构：

[1] Columbia Univ, Dept Psychiat & Neurosci, NYSPI, New York, NY 10032 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 47期

关键词：

boronic acid; benzothiazole; Suzuki coupling; palladium;

D O I：

10.1016/j.tetlet.2003.09.138

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and convergent palladium catalyzed synthesis of 2-arylbenzothiazoles has been investigated. The key step in the synthesis is a Suzuki biaryl coupling of 2-bromobenzothiazole with aryl boronic acids to provide a variety of 2-arylbenzothiazole derivatives in good yield. The synthetic utility of this methodology is demonstrated by the synthesis of 2-(4-aminophenyl)-6-methoxybenzothiazole, a PET probe precursor for the in vivo imaging of Alzheimer's disease. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：8535 / 8537

页数：3

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