Osteochondral plate angiogenesis: A new treatment target in osteoarthritis

被引：59

作者：

Pesesse, Laurence ^{[1
]}

Sanchez, Christelle ^{[1
]}

Henrotin, Yves ^{[1
]}

机构：

[1] Univ Liege, Unite Rech Os & Cartilage, Inst Pathol, CHU Sart Tilman, B-4000 Liege, Belgium

来源：

JOINT BONE SPINE | 2011年 / 78卷 / 02期

关键词：

Osteoarthritis; Angiogenesis; Cartilage; Bone; Chondrocytes; Osteoblasts; GROWTH-FACTOR VEGF; SUBCHONDRAL BONE; CHONDROMODULIN-I; ARTICULAR-CARTILAGE; ENDOTHELIAL-CELLS; MATRILYSIN MMP-7; ALKALINE-PHOSPHATASE; RHEUMATOID-ARTHRITIS; TROPONIN-I; MATRIX;

D O I：

10.1016/j.jbspin.2010.07.001

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Healthy adult joint cartilage contains neither blood vessels nor nerves. Osteoarthritic cartilage, in contrast, may be invaded by blood vessels from the subchondral bone. The mechanisms underlying cartilage angiogenesis in osteoarthritis are unclear but may involve hypertrophic chondrocyte differentiation. Active research is under way to identify the factors involved in cartilage angiogenesis. Here, we discuss the pathophysiological mechanisms of osteoarthritic cartilage angiogenesis based on evidence from a systematic literature review of articles retrieved via PubMed and ISI Web of Knowledge. Our conclusions suggest new research perspectives and treatment options. (C) 2010 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：144 / 149

页数：6

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