Osteocalcin is angiogenic in vivo

被引：37

作者：

Cantatore, FP

Crivellato, E

Nico, B

Ribatti, D

机构：

[1] Univ Bari, Sch Med, Policlin, Dept Human Anat & Histol, I-70124 Bari, Italy

[2] Univ Foggia, Sch Med, Dept Rheumatol, Foggia, Italy

[3] Univ Udine, Sch Med, Dept Med & Morphol Res, Udine, Italy

来源：

CELL BIOLOGY INTERNATIONAL | 2005年 / 29卷 / 07期

关键词：

angiogenesis; bone repair; chorioallantoic membrane; osteocalcin;

D O I：

10.1016/j.cellbi.2005.03.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The exact function of osteocalcin (OC), a protein synthesized by ostcoblasts during the matrix mineralization phase, is still unknown. In this study we investigated the capacity of OC to promote vasoproliferation in chick embryo chorioallantoic membrane (CAM), a well established in vivo assay for angiogenesis and anti-angiogenesis. The results showed that OC stimulates angiogenesis and that the response is similar to that obtained with FGF-2, a well-known angiogenic cytokine. It has previously been demonstrated that OC is involved in bone repair, so the angiogenic activity reported here might also play a crucial role in bone formation. (c) 2005 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.

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收藏

页码：583 / 585

页数：3

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