Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure

被引：82

作者：

Kley, Juliane ^{[2
]}

Schmidt, Bastian ^{[2
]}

Boyanov, Boril ^{[2
]}

Stolt-Bergner, Peggy C. ^{[2
]}

Kirk, Rebecca ^{[2
]}

Ehrmann, Michael ^{[3
]}

Knopf, Ronit R. ^{[1
]}

Naveh, Leah ^{[1
]}

Adam, Zach ^{[1
]}

Clausen, Tim ^{[2
]}

机构：

[1] Hebrew Univ Jerusalem, Robert H Smith Inst Plant Sci & Genet Agr, IL-76100 Rehovot, Israel

[2] Res Inst Mol Pathol, A-1030 Vienna, Austria

[3] Univ Duisburg Essen, Fac Biol, Ctr Med Biotechnol, Essen, Germany

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2011年 / 18卷 / 06期

基金：

以色列科学基金会;

关键词：

FTSH PROTEASE; HTRA PROTEASES; D1; PROTEIN; ARABIDOPSIS; PHOTOINHIBITION; PHOTOSYNTHESIS; MECHANISM; TURNOVER; HOMOLOG; STRESS;

D O I：

10.1038/nsmb.2055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deg1 is a chloroplastic protease involved in maintaining the photosynthetic machinery. Structural and biochemical analyses reveal that the inactive Deg1 monomer is transformed into the proteolytically active hexamer at acidic pH. The change in pH is sensed by His244, which upon protonation, repositions a specific helix to trigger oligomerization. This system ensures selective activation of Deg1 during daylight, when acidification of the thylakoid lumen occurs and photosynthetic proteins are damaged.

引用

页码：728 / 731

页数：4

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