The oxygen balance in wastewater collection systems is important in respect to the degree of biological oxidation that occurs within the stream and in respect to the control of septicity and its effects. In this paper, a simple mathematical model is presented, in order to predict dissolved oxygen concentration profiles along sanitary sewers. The mathematical model was developed based on an analytical solution of the simple differential equation of dissolved oxygen balance in sewers, and includes an empirical expression for prediction of dissolved oxygen transfer to the slime layer on the pipe walls. Because the factors controlling dissolved oxygen balance in sewers are so complex, it would be unrealistic to expect that with this rather simple model, dissolved oxygen concentrations can be accurately predicted. Nevertheless, it is reasonable to suppose that the predictions may be adequate for some design and operation purposes. Copyright (C) 1996 IAWQ.