Templating Synthesis of Preloaded Doxorubicin in Hollow Mesoporous Silica Nanospheres for Biomedical Applications

被引：165

作者：

Zhao, Yang ^{[1
]}

Lin, Li-Ning ^{[2
]}

Lu, Yang ^{[1
]}

Chen, Shao-Feng ^{[1
]}

Dong, Liang ^{[1
]}

Yu, Shu-Hong ^{[1
]}

机构：

[1] Univ Sci & Technol China, Natl Synchrotron Radiat Lab, Dept Chem, Hefei Natl Lab Phys Sci Microscale,Div Nanomat &, Hefei 230026, Anhui, Peoples R China

[2] Univ Sci & Technol China, Dept Mat Sci & Engn, Hefei 230026, Anhui, Peoples R China

来源：

ADVANCED MATERIALS | 2010年 / 22卷 / 46期

基金：

中国国家自然科学基金; 对外科技合作项目（国际科技项目）;

关键词：

DRUG-DELIVERY; DNA; MICROCAPSULES; NANOPARTICLES; NANOCARRIERS; CAPSULES; PH;

D O I：

10.1002/adma.201002395

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hollow mesoporous silica (HMS) spheres preloaded with the anticancer drug Doxorubicin (DOX) can be synthesized by using porous CaCO3 spheres as templates (see figure). With good biocompatibility, the HMS@DOX spheres exhibit a greatly enhanced therapeutic effect towards tumor cells; this enhancement may be caused by the efficient protection of DOX and the pH-sensitive release of DOX, together with enhanced intracellular delivery.

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收藏

页码：5255 / 5259

页数：5

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