Dehydroabietic acid derivatives as a novel scaffold for large-conductance calcium-activated K+ channel openers

被引：43

作者：

Ohwada, T ^{[1
]}

Nonomura, T

Maki, K

Sakamoto, K

Ohya, S

Muraki, K

Imaizumi, Y

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[2] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 22期

关键词：

D O I：

10.1016/j.bmcl.2003.08.072

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We found that the dehydroabietic acid structure is a new scaffold for chemical modulators of large-conductance calcium-activated K+ channels (BK channels). Structure-activity relationship (SAR) studies of the dehydroabietic acid derivatives and related non-aromatic compounds such as pimaric acid revealed the importance of the carboxyl functionality and an appropriate hydrophobic moiety of the molecules for BK channel-opening ability. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3971 / 3974

页数：4

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