An unexpected organocatalytic asymmetric tandem Michael/Morita-Baylis-Hillman reaction

被引：125

作者：

Cabrera, Silvia ^{[1
]}

Aleman, Jose ^{[1
]}

Bolze, Patrick ^{[1
]}

Bertelsen, Soren ^{[1
]}

Jorgensen, Karl Anker ^{[1
]}

机构：

[1] Aarhus Univ, Danish Natl Res Fdn, Ctr Catalysis, Dept Chem, DK-8000 Aarhus C, Denmark

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 01期

关键词：

aldehydes; amines; Nazarov reagent; organocatalysis; tandem reactions;

D O I：

10.1002/anie.200704076

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Simply complex: An organocatalytic tandem Michael/Morita-Baylis-Hillman reaction has been developed in which secondary amine catalysts allow for a very selective, scalable synthesis of highly substituted optically active cyclohexanones (see scheme, TMS = trimethylsilyl). Mechanistic studies indicate an active role of the secondary amine catalyst in the Morita-Baylis-Hillman reaction. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：121 / 125

页数：5

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