Ringing in the new ear: resolution of cell interactions in otic development

被引:89
作者
Riley, BB [1 ]
Phillips, BT [1 ]
机构
[1] Texas A&M Univ, Dept Biol, College Stn, TX 77843 USA
关键词
otic vesicle; hair cell; cochlea; macula; crista; vestibular; preplacodal domain; hindbrain;
D O I
10.1016/S0012-1606(03)00245-8
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The vertebrate inner ear is a marvel of structural and functional complexity, which is all the more remarkable because it develops from such a simple structure, the otic placode. Analysis of inner ear development has long been a fascination of experimental embryologists, who sought to understand cellular mechanisms of otic placode induction. More recently, however, molecular and genetic approaches have made the inner ear a useful model system for studying a much broader range of basic developmental mechanisms, including cell fate specification and differentiation, axial patterning, epithelial morphogenesis, cytoskeletal dynamics, stem cell biology, neurobiology, physiology, etc. Of course, there has also been tremendous progress in understanding the functions and processes peculiar to the inner ear. The goal of this review is to recount how historical approaches have shaped our understanding of the signaling interactions controlling early otic development: to discuss how new findings have led to fundamental new insights; and to point out new problems that need to be resolved in future research. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码:289 / 312
页数:24
相关论文
共 257 条
  • [1] Acampora D, 1999, DEVELOPMENT, V126, P3795
  • [2] Adam J, 1998, DEVELOPMENT, V125, P4645
  • [3] Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its downregulation in the ears of FGF8 mutant, ace
    Adamska, M
    Léger, S
    Brand, M
    Hadrys, T
    Braun, T
    Bober, E
    [J]. MECHANISMS OF DEVELOPMENT, 2000, 97 (1-2) : 161 - 165
  • [4] FGFs control the patterning of the inner ear but are not able to induce the full ear program
    Adamska, M
    Herbrand, H
    Adamski, M
    Krüger, M
    Braun, T
    Bober, E
    [J]. MECHANISMS OF DEVELOPMENT, 2001, 109 (02) : 303 - 313
  • [5] AKIMENKO MA, 1994, J NEUROSCI, V14, P3475
  • [6] Anagnostopoulos A. V, 2002, TRENDS GENET, V18, pS21
  • [7] Neurogenin1 defines zebrafish cranial sensory ganglia precursors
    Andermann, P
    Ungos, J
    Raible, DW
    [J]. DEVELOPMENTAL BIOLOGY, 2002, 251 (01) : 45 - 58
  • [8] ANNIKO M, 1983, DEV AUDITORY VESTIBU, P375
  • [9] Targeted disruption of mouse Dach1 results in postnatal lethality
    Backman, M
    Machon, O
    Van Den Bout, CJ
    Krauss, S
    [J]. DEVELOPMENTAL DYNAMICS, 2003, 226 (01) : 139 - 144
  • [10] Hair cell recovery in mitotically blocked cultures of the bullfrog saccule
    Baird, RA
    Burton, MD
    Fashena, DS
    Naeger, RA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (22) : 11722 - 11729