Role of Staphylococcus aureus catalase in niche competition against Streptococcus pneumoniae

被引：66

作者：

Park, Bonggoo ^{[1
,2
]}

Nizet, Victor ^{[3
]}

Liu, George Y. ^{[1
,2
]}

机构：

[1] Cedars Sinai Med Ctr, Div Pediat Infect Dis, Los Angeles, CA 90048 USA

[2] Cedars Sinai Med Ctr, Immunobiol Res Inst, Los Angeles, CA 90048 USA

[3] Univ Calif San Diego, Sch Med, Div Pharmacol & Drug Discovery, Dept Pediat, La Jolla, CA 92093 USA

来源：

JOURNAL OF BACTERIOLOGY | 2008年 / 190卷 / 07期

关键词：

D O I：

10.1128/JB.00006-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nasal colonization by Staphylococcus aureus is a major predisposing factor for subsequent infection. Recent reports of increased S. aureus colonization among children receiving pneumococcal vaccine implicate Streptococcus pneumoniae as an important competitor for the same niche. Since S. pneumoniae uses H2O2 to kill competing bacteria, we hypothesized that oxidant defense could play a significant role in promoting S. aureus colonization of the nasal mucosa. Using targeted mutagenesis, we showed that S. aureus expression of catalase contributes significantly to the survival of this pathogen in the presence of S. pneumoniae both in vitro and in a murine model of nasal cocolonization.

引用

页码：2275 / 2278

页数：4

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