Glucose neurotoxicity

被引:436
作者
Tomlinson, David R. [1 ]
Gardiner, Natalie J. [1 ]
机构
[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England
关键词
D O I
10.1038/nrn2294
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neurons have a constantly high glucose demand, and unlike muscle cells they cannot accommodate episodic glucose uptake under the influence of insulin. Neuronal glucose uptake depends on the extracellular concentration of glucose, and cellular damage can ensue after persistent episodes of hyperglycaemia - a phenomenon referred to as glucose neurotoxicity. This article reviews the pathophysiological manifestation of raised glucose in neurons and how this can explain the major components of diabetic neuropathy.
引用
收藏
页码:36 / 45
页数:10
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