Diabetes and stroke: Part one - Risk factors and pathophysiology

被引:22
作者
Baliga B.S. [1 ]
Weinberger J. [1 ]
机构
[1] Division of Endocrinology and Metabolism, North General Hospital, New York, NY 10031
关键词
Metabolic Syndrome; Ischemic Stroke; Hyperglycemia; Hemorrhagic Stroke; Nondiabetic Subject;
D O I
10.1007/s11886-006-0006-1
中图分类号
学科分类号
摘要
Diabetes is a major risk factor for stroke and is associated with an increase in overall stroke mortality. The metabolic syndrome associated with insulin resistance is also a significant risk factor for stroke. The etiology of stroke in diabetics is frequently microvascular disease from fibrinoid necrosis, which causes small subcortical infarcts designated as lacunar strokes. Diabetics also have an increased incidence of large vessel intracranial vascular disease. Although strict control of blood sugar has not been shown to reduce the overall incidence of stroke in diabetics, careful management of other associated risk factors, particularly hypercholesterolemia and hypertension, are imperative for the prevention of stroke in diabetic patients. Copyright © 2006 by Current Science Inc.
引用
收藏
页码:23 / 28
页数:5
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共 80 条
[1]  
Rosamond W.D., Folsom A.R., Chambless L.E., Et al., Stroke incidence and survival among middle-aged adults: 9-year follow-up of the Atherosclerosis Risk in Communities (ARIC) cohort, Stroke, 30, pp. 736-743, (1999)
[2]  
2001 Heart and Stroke Statistical Update, (2001)
[3]  
Murray C.J., Lopez A.D., Mortality by cause for eight regions of the world: Global burden of disease study, Lancet, 349, pp. 1269-1276, (1997)
[4]  
Geiss L.S., Herman W.H., Smith P.J., Mortality in non-insulin-dependent diabetes, Diabetes in America, 1995, pp. 233-258
[5]  
Folsom A.R., Rasmussen M.L., Chambless M.E., Et al., Prospective associations of fasting insulin, body fat distribution, and diabetes with risk of ischemic stroke, Diabetes Care, 22, pp. 1077-1083, (1999)
[6]  
Katakura M., Naka M., Kondo T., Et al., Prospective analysis of mortality, morbidity, and risk factors in elderly diabetic subjects: Nagano study, Diabetes Care, 26, pp. 638-644, (2003)
[7]  
Currie C.J., Morgan C.L., Gill L., Et al., Epidemiology and costs of acute hospital care for cerebrovascular disease in diabetic and nondiabetic populations, Stroke, 28, pp. 1142-1146, (1997)
[8]  
Luchsinger J.A., Tang M.X., Stern Y., Et al., Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multiethnic cohort, Am J Epidemiol, 154, pp. 635-641, (2001)
[9]  
Stamler J., Vaccaro O., Neaton J.D., Et al., Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial, Diabetes Care, 16, pp. 434-444, (1993)
[10]  
Rohr J., Kittner S., Feeser B., Et al., Traditional risk factors and ischemic stroke in young adults: The Baltimore-Washington Cooperative Young Stroke Study, Arch Neurol, 53, pp. 603-607, (1996)