Respiratory disease in kennelled dogs:: Serological responses to Bordetella bronchiseptica lipopolysaccharide do not correlate with bacterial isolation or clinical respiratory symptoms

被引：34

作者：

Chalker, VJ ^{[1
]}

Toomey, C ^{[1
]}

Opperman, S ^{[1
]}

Brooks, HW ^{[1
]}

Ibuoye, MA ^{[1
]}

Brownlie, J ^{[1
]}

Rycroft, AN ^{[1
]}

机构：

[1] Univ London, Univ London Royal Vet Coll, Dept Pathol & Infect Dis, N Mymms AL9 7TA, Herts, England

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2003年 / 10卷 / 03期

关键词：

D O I：

10.1128/CDLI.10.3.352-356.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of Bordetella bronchiseptica in a natural outbreak of canine infectious respiratory disease was investigated both by culture and serological analysis. B. bronchiseptica was found in the lungs of a large proportion of clinically healthy dogs and in a greater proportion of dogs with respiratory disease. Using a lipopolysaccharide (LPS) antigen-based enzyme-linked immunosorbent assay, we analyzed the serological responses of a large number of dogs. Dogs with high antibody levels showed no protection from disease, and there was no correlation between the development of disease and rising antibody titer. Similarly, there was no difference in antibody levels in dogs with and without B. bronchiseptica in the lungs. Antibodies to LPS have no predictive value in determining which animals will contract respiratory disease, how severe the disease will be, or which dogs will have B. bronchiseptica colonizing the lungs.

引用

页码：352 / 356

页数：5

共 33 条

[21] Role of Bordetella bronchiseptica fimbriae in tracheal colonization and development of a humoral immune response [J].