Building a stage for interhelical play in rhodopsin

被引：8

作者：

Abdulaev, NG

机构：

[1] Univ Maryland, Inst Biotechnol, Ctr Adv Res Biotechnol, Rockville, MD 20850 USA

[2] Natl Inst Stand & Technol, Rockville, MD 20850 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2003年 / 28卷 / 08期

关键词：

D O I：

10.1016/S0968-0004(03)00164-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biochemical data providing new insights into the packing of helices I and 11 in the transmembrane domain of rhodopsin reveals the existence of a specific set of size- and charge-sensitive interhelical interactions that influence protein tertiary structure. These findings have broad implications towards understanding the molecular consequences of naturally occurring mutations associated with the retinal degenerative disease autosomal dominant retinitis pigmentosa.

引用

收藏

页码：399 / 402

页数：4

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