Determination of acetylsalicylic acid in tablets with salicylate ion selective electrode in a batch injection analysis system

The feasibility of the use of a Batch Injection Analysis (BIA) system for potentiometric determination of acetylsalicylic acid in tablets, with a membrane ion selective electrode, was investigated. There is no significant difference between the results obtained by the proposed method(12) at the 95% confidence level. and those obtained by the Standard British Pharmacopaeia method Values of 4% and 2.5% for R.S.D. were obtained by the application of the BIA-potentiometric method and for the injections respectively. About 90 determinations per hour can be performed with the proposed BIA potentiometric method.