Relationship between polypharmacy and underprescribing

被引：182

作者：

Kuijpers, Mascha A. J. ^{[1
]}

van Marum, Rob J. ^{[1
]}

Egberts, Antoine C. G. ^{[2
,3
]}

Jansen, Paul A. F. ^{[1
]}

机构：

[1] Univ Med Ctr, Dept Geriatr Med, NL-3508 GA Utrecht, Netherlands

[2] Univ Med Ctr, Dept Clin Pharm, NL-3508 GA Utrecht, Netherlands

[3] Univ Utrecht, Div Pharmacoepidemiol & Pharmacotherapy, Utrecht Inst Pharmaceut Sci, Fac Sci, Utrecht, Netherlands

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2008年 / 65卷 / 01期

关键词：

elderly; polypharmacy; underprescribing;

D O I：

10.1111/j.1365-2125.2007.02961.x

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

AIMS Underprescribing is increasingly recognized as an important problem. The aim of this study was to determine the relationship between polypharmacy and underprescribing. METHODS Treatment of current medical problems in geriatric patients was compared with general practitioner and national guidelines. Underprescription was defined as lack of an indicated drug, while no reason could be found for not prescribing it. Polypharmacy was defined as five or more drugs. RESULTS Polypharmacy was present in 61% of 150 patients. Underprescription was found in 47 (31%). Of patients with polypharmacy 42.9% were undertreated, in contrast to 13.5% of patients using four medicines or less (OR 4.8, 95% CI 2.0, 11.2). The estimated probability of underprescription increased significantly with the number of drugs. CONCLUSIONS We found a clear relationship between polypharmacy and underprescribing.

引用

页码：130 / 133

页数：4

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