Pain TRPs

被引：113

作者：

Wang, HB

Woolf, CJ ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Dept Anesthesia & Crit Care, Neural Plast Res Grp, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Charlestown, MA 02129 USA

来源：

NEURON | 2005年 / 46卷 / 01期

关键词：

D O I：

10.1016/j.neuron.2005.03.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Transient receptor potential (TRIP) ion channels are molecular gateways in sensory systems, an interface between the environment and the nervous system. Several TRPs transduce thermal, chemical, and mechanical stimuli into inward currents, an essential first step for eliciting thermal and pain sensations. Precise regulation of the expression, localization, and function of the TRP channels is crucial for their sensory role in nociceptor terminals, particularly after inflammation, when they contribute to pain hypersensitivity by undergoing changes in translation and trafficking as well as diverse posttranslational modifications.

引用

收藏

页码：9 / 12

页数：4

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