The adenylyl and guanylyl cyclase superfamily

被引：68

作者：

Hurley, JH ^{[1
]}

机构：

[1] NIDDKD, Mol Biol Lab, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1998年 / 8卷 / 06期

关键词：

D O I：

10.1016/S0959-440X(98)80097-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New structures solved in 1997 revealed that the adenylyl cyclase core consists of a pair of catalytic domains arranged in a wreath. Homologous catalytic domains are arranged in diverse adenylyl and guanylyl cyclases as symmetric homodimers or pseudosymmetric heterodimers. The kinship of the adenylyl and guanylyl cyclases has been confirmed by the structure-based interconversion of their nucleotide specificities. Catalysis is activated when two metal-binding aspartate residues on one domain are juxtaposed with a key aspargine-arginine pair on the other. Allosteric activators of mammalian adenylyl cyclase, forskolin and the stimulatory G protein alpha subunit, promote the catalytically optimal juxtaposition of the two domains.

引用

收藏

页码：770 / 777

页数：8

相关论文

共 41 条

[11]

GARBERS DL, 1994, J BIOL CHEM, V269, P30741

[12] Adenylyl cyclases: Structure, regulation and function in an enzyme superfamily [J].

Hanoune, J ;

Pouille, Y ;

Tzavara, E ;

Shen, TS ;

Lipskaya, L ;

Miyamoto, N ;

Suzuki, Y ;

Defer, N .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1997, 128 (1-2) :179-194

[13] Tailoring cAMP-signalling responses through isoform multiplicity [J].

Houslay, MD ;

Milligan, G .

TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (06) :217-224

[14]

KOCH KW, 1990, J BIOL CHEM, V265, P9659

[15] ADENYLYL CYCLASE AMINO-ACID SEQUENCE - POSSIBLE CHANNEL-LIKE OR TRANSPORTER-LIKE STRUCTURE [J].

KRUPINSKI, J ;

COUSSEN, F ;

BAKALYAR, HA ;

TANG, WJ ;

FEINSTEIN, PG ;

ORTH, K ;

SLAUGHTER, C ;

REED, RR ;

GILMAN, AG .

SCIENCE, 1989, 244 (4912) :1558-1564

[16] FORSKOLIN - A SPECIFIC STIMULATOR OF ADENYLYL CYCLASE OR A DITERPENE WITH MULTIPLE SITES OF ACTION [J].

LAURENZA, A ;

SUTKOWSKI, EM ;

SEAMON, KB .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (11) :442-447

[17] Catalytic mechanism of the adenylyl and guanylyl cyclases: Modeling and mutational analysis [J].

Liu, Y ;

Ruoho, AE ;

Rao, VD ;

Hurley, JH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) :13414-13419

[18] Constitutively active adenylyl cyclase mutant requires neither G proteins nor cytosolic regulators [J].

Parent, CA ;

Devreotes, PN .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (31) :18333-18336

[19] Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: Evidence for an induced fit mechanism [J].

Sawaya, MR ;

Prasad, R ;

Wilson, SH ;

Kraut, J ;

Pelletier, H .

BIOCHEMISTRY, 1997, 36 (37) :11205-11215

[20] Characterization of soluble forms of nonchimeric type V adenylyl cyclases [J].

Scholich, K ;

Barbier, AJ ;

Mullenix, JB ;

Patel, TB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (07) :2915-2920

← 1 2 3 4 5 →