Antibodies come back from the brink

被引:28
作者
Holliger, P
Hoogenboom, H
机构
[1] MRC, Ctr Prot Engn, Cambridge CB2 2QH, England
[2] Univ Hosp Maastricht, Dept Pathol, CESAME, NL-6202 AZ Maastricht, Netherlands
关键词
D O I
10.1038/3460
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
[No abstract available]
引用
收藏
页码:1015 / 1016
页数:2
相关论文
共 10 条
[1]   Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial library [J].
Begent, RHJ ;
Verhaar, MJ ;
Chester, KA ;
Casey, JL ;
Green, AJ ;
Napier, MP ;
HopeStone, LD ;
Cushen, N ;
Keep, PA ;
Johnson, CJ ;
Hawkins, RE ;
Hilson, AJW ;
Robson, L .
NATURE MEDICINE, 1996, 2 (09) :979-984
[2]   Retargeting serum immunoglobulin with bispecific diabodies [J].
Holliger, P ;
Wing, M ;
Pound, JD ;
Bohlen, H ;
Winter, G .
NATURE BIOTECHNOLOGY, 1997, 15 (07) :632-636
[3]   Antibody phage display technology and its applications [J].
Hoogenboom, HR ;
de Bruine, AP ;
Hufton, SE ;
Hoet, RM ;
Arends, JW ;
Roovers, RC .
IMMUNOTECHNOLOGY, 1998, 4 (01) :1-20
[4]   CONTINUOUS CULTURES OF FUSED CELLS SECRETING ANTIBODY OF PREDEFINED SPECIFICITY [J].
KOHLER, G ;
MILSTEIN, C .
NATURE, 1975, 256 (5517) :495-497
[5]   An efficient route to human bispecific IgG [J].
Merchant, AM ;
Zhu, ZP ;
Yuan, JQ ;
Goddard, A ;
Adams, CW ;
Presta, LG ;
Carter, P .
NATURE BIOTECHNOLOGY, 1998, 16 (07) :677-681
[6]   THE CROONIAN LECTURE, 1989 - ANTIBODIES - A PARADIGM FOR THE BIOLOGY OF MOLECULAR RECOGNITION [J].
MILSTEIN, C .
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1990, 239 (1294) :1-16
[7]   HYBRID HYBRIDOMAS AND THEIR USE IN IMMUNOHISTOCHEMISTRY [J].
MILSTEIN, C ;
CUELLO, AC .
NATURE, 1983, 305 (5934) :537-540
[8]   Monoclonal antibody therapy for resected Dukes' C colorectal cancer:: Seven-year outcome of a multicenter randomized trial [J].
Riethmüller, G ;
Holz, E ;
Schlimok, G ;
Schmiegel, W ;
Raab, R ;
Höffken, K ;
Gruber, R ;
Funke, I ;
Pichlmaier, H ;
Hirche, H ;
Buggisch, P ;
Witte, J ;
Pichlmayr, R .
JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (05) :1788-1794
[9]   Synthetic human antibodies and a strategy for protein engineering [J].
Winter, G .
FEBS LETTERS, 1998, 430 (1-2) :92-94
[10]   MAN-MADE ANTIBODIES [J].
WINTER, G ;
MILSTEIN, C .
NATURE, 1991, 349 (6307) :293-299