Synthetic human antibodies and a strategy for protein engineering

被引:41
作者
Winter, G
机构
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
[2] MRC, Ctr Prot Engn, Cambridge CB2 2QH, England
关键词
antibody engineering; synthetic antibody; phage display;
D O I
10.1016/S0014-5793(98)00628-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Our understanding of the way antibodies are built in vivo has provided an approach for engineering synthetic human antibodies in bacteria. Such antibodies have not only been raised against foreign antigens, but also against highly conserved antigens or human self-antigens, and have considerable practical potential as reagents for research and also as therapeutics. The approach also has implications for the design of antibody repertoires and for engineering other proteins,vith desirable binding properties. This review takes a personal view. (C) 1998 Federation of European Biochemical Societies.
引用
收藏
页码:92 / 94
页数:3
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