Inactivation of the anterior cingulate cortex blocks expression of remote, but not recent, conditioned taste aversion memory

被引：51

作者：

Ding, Hoi Ki ^{[1
,2
]}

Teixeira, Catia M. ^{[1
,3
]}

Frankland, Paul W. ^{[1
,2
,4
]}

机构：

[1] Hosp Sick Children, Program Neurosci & Mental Hlth, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada

[3] Univ Porto, GABBA, Grad Program Areas Basic & Appl Biol, P-4050465 Oporto, Portugal

[4] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A8, Canada

来源：

LEARNING & MEMORY | 2008年 / 15卷 / 05期

关键词：

D O I：

10.1101/lm.905008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies have shown that medial prefrontal cortical regions, such as the anterior cingulate cortex (ACC), play a key role in the expression of remote spatial and contextual memory. To evaluate whether this role is conserved in hippocampal-independent tasks we trained mice in the conditioned taste aversion (CTA) paradigm. Lidocaine-induced inactivation of the ACC blocked the expression of CTA tested one month ( remote), but not one day (recent), after conditioning with either a weak or strong unconditioned stimulus (US). These data suggest that the ACC may play a conserved role in remote memory, regardless of memory strength or content.

引用

页码：290 / 293

页数：4

共 20 条

[1] Molecular mechanisms of taste-recognition memory [J].