Differential modulation of brain immediate early genes by intraperitoneal LiCl

被引：40

作者：

Lamprecht, R ^{[1
]}

Dudai, Y ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT NEUROBIOL,IL-76100 REHOVOT,ISRAEL

来源：

NEUROREPORT | 1995年 / 7卷 / 01期

关键词：

conditioned taste aversion; immediate early genes; c-fos; zif/268; fos-B; CREM;

D O I：

10.1097/00001756-199512290-00069

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE have used in situ hybridization to investigate the modulation of expression of the immediate early genes (IEGs) c-fos, fos-B, zif/268 and CREM in rat brain following oral administration of saccharin, i.p. injection of LiCl, and conditioned taste aversion (CTA) training in which these stimuli are used as the conditioned stimulus (CS) and the unconditioned stimulus (UCS), respectively. Modulation of c-fos, zif/268 and CREM was detected in the NTS, PBN, hypothalamic PVN and central nucleus of the amygdala after the administration of the UCS but not the CS. Our data are consonant with the hypothesis that differential and combinatorial expression of IEGs plays a role in encoding the representation of LiCl-induced malaise in the brain.

引用

页码：289 / 293

页数：5

共 22 条

[1]

Dudai Y, 1989, NEUROBIOLOGY MEMORY

[2]

GARCIA J, 1955, SCIENCE, V122, P157

[3] THE LONG AND THE SHORT OF LONG-TERM-MEMORY - A MOLECULAR FRAMEWORK [J].

GOELET, P ;

CASTELLUCCI, VF ;

SCHACHER, S ;

KANDEL, ER .

NATURE, 1986, 322 (6078) :419-422

[4] EXPRESSION OF C-FOS IN BRAIN SUBCORTICAL STRUCTURES IN RESPONSE TO NAUSEANT LITHIUM-CHLORIDE AND OSMOTIC-PRESSURE IN RATS [J].

GU, Y ;

GONZALEZ, MF ;

CHEN, DY ;

DEUTSCH, JA .

NEUROSCIENCE LETTERS, 1993, 157 (01) :49-52

[5] MECHANISMS OF COMPLEX TRANSCRIPTIONAL REGULATION - IMPLICATIONS FOR BRAIN-DEVELOPMENT [J].

HE, X ;

ROSENFELD, MG .

NEURON, 1991, 7 (02) :183-196

[6] INDUCTION OF MULTIPLE IMMEDIATE-EARLY GENES IN RAT HYPOTHALAMIC PARAVENTRICULAR NUCLEUS AFTER STRESS [J].

HONKANIEMI, J ;

KONONEN, J ;

KAINU, T ;

PYYKONEN, I ;

PELTOHUIKKO, M .

MOLECULAR BRAIN RESEARCH, 1994, 25 (3-4) :234-241

[7] FOS AND JUN IN RAT CENTRAL AMYGDALOID NUCLEUS AND PARAVENTRICULAR NUCLEUS AFTER STRESS [J].

HONKANIEMI, J ;

KAINU, T ;

CECCATELLI, S ;

RECHARDT, L ;

HOKFELT, T ;

PELTOHUIKKO, M .

NEUROREPORT, 1992, 3 (10) :849-852

[8] INCREASED C-FOS EXPRESSION IN NUCLEUS OF THE SOLITARY TRACT CORRELATED WITH CONDITIONED TASTE-AVERSION TO SUCROSE IN RATS [J].

HOUPT, TA ;

PHILOPENA, JM ;

WESSEL, TC ;

JOH, TH ;

SMITH, GP .

NEUROSCIENCE LETTERS, 1994, 172 (1-2) :1-5

[9] THE STRESS-ACTIVATED PROTEIN-KINASE SUBFAMILY OF C-JUN KINASES [J].

KYRIAKIS, JM ;

BANERJEE, P ;

NIKOLAKAKI, E ;

DAI, TA ;

RUBIE, EA ;

AHMAD, MF ;

AVRUCH, J ;

WOODGETT, JR .

NATURE, 1994, 369 (6476) :156-160

[10] NUMEROUS CANDIDATE PLASTICITY-RELATED GENES REVEALED BY DIFFERENTIAL CDNA CLONING [J].

NEDIVI, E ;

HEVRONI, D ;

NAOT, D ;

ISRAELI, D ;

CITRI, Y .

NATURE, 1993, 363 (6431) :718-722

← 1 2 3 →