Twofold C-H functionalization:: Palladium-catalyzed ortho arylation of anilides

被引：274

作者：

Brasche, Gordon ^{[1
]}

Garcia-Fortanet, Jorge ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 11期

关键词：

D O I：

10.1021/ol800619c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The ortho arylation of anilides to form biphenyls via a twofold C-H functionalization/C-C bond-forming process is described. The oxidative coupling takes place in the presence of 5-10 mol % of Pd(OAC)(2), 10-20 mol % of DMSO, and 4-11 equiv of the aryl substrate in TFA under an oxygen atmosphere. No metal-containing cocatalyst is required.

引用

页码：2207 / 2210

页数：4

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