Wnt signaling: the good and the bad

被引：35

作者：

Chen, Xi ^{[1
]}

Yang, Jun ^{[1
]}

Evans, Paul M. ^{[1
]}

Liu, Chunming ^{[1
]}

机构：

[1] Univ Texas Med Branch, Dept Biochem & Mol Biol, Sealy Ctr Canc Cell Biol, Galveston, TX 77555 USA

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2008年 / 40卷 / 07期

关键词：

Wnt signaling; beta-catenin; cancer; stem cell;

D O I：

10.1111/j.1745-7270.2008.00440.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since the first Wnt gene was identified in 1982, the functions and mechanisms of Wnt signaling have been extensively studied. Wnt signaling is conserved from invertebrates to vertebrates and regulates early embryonic development as well as the homeostasis of adult tissues. In addition, both embryonic stem cells and adult stem cells are regulated by Wnt signaling. Deregulation of Wnt signaling is associated with many human diseases, particularly cancers. In this review, we will discuss in detail the functions of many components involved in the Wnt signal transduction pathway. Then, we will explore what is known about the role of Wnt signaling in stem cells and cancers.

引用

页码：577 / 594

页数：18

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