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Signaling by Eph receptors and their ephrin ligands

被引：125
作者：
Brückner, K [1 ]
Klein, R [1 ]
机构：
[1] European Mol Biol Lab, D-69117 Heidelberg, Germany
来源：
CURRENT OPINION IN NEUROBIOLOGY | 1998年 / 8卷 / 03期
关键词：
D O I：
10.1016/S0959-4388(98)80064-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
What are the mechanisms by which Eph receptor tyrosine kinases guide axons and migrating cells? Recent results show that Eph receptors bind some of the well-known effector molecules that are implicated in the organization of the actin cytoskeleton; moreover, biochemical and genetic evidence suggests a signaling role for transmembrane ephrin ligands in axon pathfinding.
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页码：375 / 382
页数：8
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