Serotonin-induced enhancement of vasopressin and oxytocin secretion in rat neurohypophyseal tissue culture

被引：34

作者：

Gálfi, M

Radács, M

Juhász, A

László, F

Molnár, A

László, FA

机构：

[1] Univ Szeged, Dept Comparat Physiol, H-6720 Szeged, Hungary

[2] Univ Szeged, Fac Juhasz Gyula, Teachers Training Coll, Dept Biol, H-6720 Szeged, Hungary

[3] Univ Sci, Dept Psychiat, Szeged, Hungary

[4] Hungarian Acad Sci, Inst Expt Med, Budapest, Hungary

来源：

REGULATORY PEPTIDES | 2005年 / 127卷 / 1-3期

基金：

英国医学研究理事会; 匈牙利科学研究基金会;

关键词：

vasopressin; oxytocin; neurohypophyseal tissue culture; serotonin regulation; serotonin antagonist; WAY-100635; ketanserin; metergoline;

D O I：

10.1016/j.regpep.2004.12.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of serotonin (5-hydroxytryptamine; 5-HT) on vasopressin (VP) and oxytocin (OT) secretion were studied in 13-14-day cultures of isolated rat neurohypophyseal (NH) tissue. The VP and OT contents of the supernatant were determined by radioimmunassay after a 1 or 2 h incubation. Significantly increased levels of VP and OT production were detected in the tissue culture media following 5-HT administration, depending on the 5-HT dose. The elevation of NTH hormone secretion could be partially blocked by previous administration of the 5-HT antagonist ketanserin or metergoline. WAY-100635 did not influence the increased VP secretion induced by 5-HT, but the elevated OT production was prevented by WAY-100635 before 5-HT administration. The application of WAY-100635, ketanserin or metergoline, after 5-HT administration proved ineffective. The results indicate that NH hormone release is influenced directly by the serotonergic system. The serotonergic control of VP and OT secretion from the NH tissue in rats can occur at the level of the posterior pituitary. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：225 / 231

页数：7

共 46 条

[11] Inhibitory effect of galanin on dopamine induced increased oxytocin secretion in rat neurohypophyseal tissue cultures [J].