An insight into the role of citrus bioactives in modulation of colon cancer

被引：48

作者：

Kaur, Jasleen ^{[1
]}

Kaur, Gurpreet ^{[1
]}

机构：

[1] Punjabi Univ, Dept Pharmaceut Sci, Patiala 147002, Punjab, India

来源：

JOURNAL OF FUNCTIONAL FOODS | 2015年 / 13卷

关键词：

Citrus flavanones; Polymethoxyflavones; Limonene; Auraptene antiproliferative action; Citrus limonoids; ABERRANT CRYPT FOCI; CELL-CYCLE ARREST; MALE F344 RATS; COLORECTAL-CANCER; D-LIMONENE; PRENEOPLASTIC LESIONS; ANTICANCER ACTIVITY; NARINGENIN DERIVATIVES; INHIBITS ANGIOGENESIS; LIQUID-CHROMATOGRAPHY;

D O I：

10.1016/j.jff.2014.12.043

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Citrus fruits are important health promoting fruits rich in a number of bioactive components mainly flavonoids, limonoids, coumarins, volatile oils and carotenoids. Citrus bioactives have been found to scavenge reactive oxygen species, rejuvenate body's own antioxidant enzymes, inhibit various signalling pathways, act on extrinsic and intrinsic apoptotic pathways, suppress inflammatory mediators and arrest the cell cycle. Cancer is the second leading cause of death worldwide after cardiovascular diseases and colon cancer is the third most common cancer worldwide. Studies have suggested a positive relation between diet rich in natural phytochemicals and reduced risk of colon cancer. The present review highlights the chemopreventive action of various citrus phytochemicals in colon cancer. The studies suggest that citrus bioactives either alone or in combination with current therapeutic agents can be developed as potential drug candidates for colon cancer. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：239 / 261

页数：23

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