Human embryonic stem cells as a model for nutritional programming: An evaluation

被引：17

作者：

Allegrucci, C ^{[1
]}

Denning, CN ^{[1
]}

Burridge, P ^{[1
]}

Steele, W ^{[1
]}

Sinclair, KD ^{[1
]}

Young, LE ^{[1
]}

机构：

[1] Univ Nottingham, Nottingham NG7 2UH, England

来源：

REPRODUCTIVE TOXICOLOGY | 2005年 / 20卷 / 03期

基金：

英国医学研究理事会;

关键词：

developmental origins of adult disease; embryo; nutritional programming; DNA methylation; human embryonic stem cells; folate;

D O I：

10.1016/j.reprotox.2005.04.010

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Our laboratory is evaluating whether an epigenetic mechanism involving alterations in DNA methylation can alter the trajectory of embryonic/fetal development in response to maternal nutrients. A similar mechanism may operate in embryo culture environments commonly used in human assisted conception. Since developmental studies on early human embryos in utero are obviously not possible, we have begun to investigate the utility of human,embryonic stern cells (hESC) to uncover potential programming mechanisms. This review highlights some of the advantages and problems associated with such a model and suggests that these issues are also broadly applicable to utility of hESC for more general toxicology and drug screening applications. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：353 / 367

页数：15

共 136 条

[61] LANE M, 1994, J REPROD FERTIL, V102, P305, DOI 10.1530/jrf.0.1020305
[62] Fetal programming of cardiovascular function through exposure to maternal undernutrition
Langley-Evans, SC
[J]. PROCEEDINGS OF THE NUTRITION SOCIETY, 2001, 60 (04) : 505 - 513
[63] Lau Christopher, 2004, Birth Defects Res C Embryo Today, V72, P300, DOI 10.1002/bdrc.20029
[64] Effects of moderate alcohol consumption on folate and vitamin B12 status in postmenopausal women
Laufer, EM
Hartman, TJ
Baer, DJ
Gunter, EW
Dorgan, JF
Campbell, WS
Clevidence, BA
Brown, ED
Albanes, D
Judd, JT
Taylor, PR
[J]. EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2004, 58 (11) : 1518 - 1524
[65] Advances in tissue engineering
Levenberg, S
Langer, R
[J]. CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, VOL. 61, 2004, 61 : 113 - +
[66] Gene regulatory networks for development
Levine, M
Davidson, EH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (14) : 4936 - 4942
[67] Liu X, 1997, DEV DYNAM, V209, P85
[68] A genetic regulatory network for Xenopus mesendoderm formation
Loose, M
Patient, R
[J]. DEVELOPMENTAL BIOLOGY, 2004, 271 (02) : 467 - 478
[69] Folic acid - vitamin and panacea or genetic time bomb?
Lucock, M
Yates, Z
[J]. NATURE REVIEWS GENETICS, 2005, 6 (03) : 235 - 240
[70] Is folic acid the ultimate functional food component for disease prevention?
Lucock, M
[J]. BMJ-BRITISH MEDICAL JOURNAL, 2004, 328 (7433): : 211 - 214

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