Effect of Nanoparticle Surface Charge at the Plasma Membrane and Beyond

被引：492

作者：

Arvizo, Rochelle R. ^{[1
]}

Miranda, Oscar R. ^{[5
]}

Thompson, Michael A. ^{[2
]}

Pabelick, Christina M. ^{[2
,3
]}

Bhattacharya, Resham ^{[1
]}

Robertson, J. David ^{[6
,7
]}

Rotello, Vincent M. ^{[5
]}

Prakash, Y. S. ^{[2
,3
]}

Mukherjee, Priyabrata ^{[1
,3
,4
]}

机构：

[1] Mayo Clin, Coll Med, Dept Biochem & Mol Biol, Rochester, MN 55905 USA

[2] Mayo Clin, Coll Med, Dept Anesthesiol, Rochester, MN 55905 USA

[3] Mayo Clin, Coll Med, Dept Physiol & Biomed Engn, Rochester, MN 55905 USA

[4] Mayo Clin, Coll Med, Mayo Clin Canc Ctr, Rochester, MN 55905 USA

[5] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

[6] Univ Missouri, Dept Chem, Columbia, MO 65211 USA

[7] Univ Missouri, Univ Missouri Res Reactor, Columbia, MO 65211 USA

来源：

NANO LETTERS | 2010年 / 10卷 / 07期

关键词：

Gold nanoparticles; surface properties; cancer; membrane potential; calcium; apoptosis; GOLD NANOPARTICLES; SMOOTH-MUSCLE; CALCIUM; CANCER; NANOTECHNOLOGY; CHEMISTRY; NANOCRYSTALS; DELIVERY; CHANNELS; BIOLOGY;

D O I：

10.1021/nl101140t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we demonstrate that the surface charge of gold nanoparticles (AuNPs) plays a critical role in modulating membrane potential of different malignant and nonmalignant cell types and subsequent downstream intracellular events The findings presented here describe a novel mechanism for cell-nanoparticle interactions and AuNP uptake modulation of membrane potential and its effect on intracellular events. These studies will help understand the biology of cell-nanoparticle interactions and facilitate the engineering of nanoparticles for specific intracellular targets

引用

页码：2543 / 2548

页数：6

共 28 条

[1] The use of nanocrystals in biological detection [J].

Alivisatos, P .

NATURE BIOTECHNOLOGY, 2004, 22 (01) :47-52

[2] Role of mitochondria in spontaneous rhythmic activity and intracellular calcium waves in the guinea pig gallbladder smooth muscle [J].

Balemba, Onesmo B. ;

Bartoo, Aaron C. ;

Nelson, Mark T. ;

Mawe, Gary M. .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2008, 294 (02) :G467-G476

[3]

BEHRENS BC, 1987, CANCER RES, V47, P414

[4] Attaching folic acid on gold nanoparticles using noncovalent interaction via different polyethylene glycol backbones and targeting of cancer cells [J].

Bhattacharya, Resham ;

Patra, Chitta Ranjan ;

Earl, Alexis ;

Wang, Shanfeng ;

Katarya, Aaron ;

Lu, Lichun ;

Kizhakkedathu, Jayachandran N. ;

Yaszemski, Michael J. ;

Greipp, Philip R. ;

Mukhopadhyay, Debabrata ;

Mukherjee, Priyabrata .

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2007, 3 (03) :224-238

[5] SYNTHESIS OF THIOL-DERIVATIZED GOLD NANOPARTICLES IN A 2-PHASE LIQUID-LIQUID SYSTEM [J].

BRUST, M ;

WALKER, M ;

BETHELL, D ;

SCHIFFRIN, DJ ;

WHYMAN, R .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1994, (07) :801-802

[6] Chemistry and properties of nanocrystals of different shapes [J].

Burda, C ;

Chen, XB ;

Narayanan, R ;

El-Sayed, MA .

CHEMICAL REVIEWS, 2005, 105 (04) :1025-1102

[7] Calcium signaling in non-excitable cells:: Ca2+ release and influx are independent events linked to two plasma membrane Ca2+ entry channels [J].

Chakrabarti, Ranjana ;

Chakrabarti, Rabindranath .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2006, 99 (06) :1503-1516

[8] Gold nanoparticles: Assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology [J].

Daniel, MC ;

Astruc, D .

CHEMICAL REVIEWS, 2004, 104 (01) :293-346

[9] Cancer nanotechnology: Opportunities and challenges [J].

Ferrari, M .

NATURE REVIEWS CANCER, 2005, 5 (03) :161-171

[10]

Fulcher M Leslie, 2005, Methods Mol Med, V107, P183

← 1 2 3 →