Chromatin states in pluripotent, differentiated, and reprogrammed cells

被引：127

作者：

Fisher, Cynthia L. ^{[1
]}

Fisher, Amanda G. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Sch Med, MRC Clin Sci Ctr, Lymphocyte Dev Grp, London W12 0NN, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2011年 / 21卷 / 02期

基金：

英国医学研究理事会;

关键词：

EMBRYONIC STEM-CELLS; TRANSCRIPTIONAL REGULATORY CIRCUITRY; RNA-POLYMERASE-II; SELF-RENEWAL; DNA METHYLATION; INTERACTION NETWORK; LINEAGE COMMITMENT; REMODELING COMPLEX; BIVALENT GENES; GENOME;

D O I：

10.1016/j.gde.2011.01.015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The pluripotent state of embryonic stem cells is maintained by a core network of transcription factors, and by chromatin remodelling factors that support an environment permissive for transcription. Polycomb and trithorax Group proteins enable 'bivalent' chromatin to be established at lineage-specific genes within pluripotent cells that is thought to poise genes for rapid activation upon induction of differentiation. As differentiation proceeds, chromatin condenses and there is a genome-wide increase in the abundance of repressive histone modifications, alterations in the subnuclear organisation of particular genomic regions, and changes in DNA methylation profiles within genes. Reprogramming of somatic cells provides a platform to investigate the role of chromatin-based factors in establishing and maintaining pluripotency.

引用

页码：140 / 146

页数：7

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