The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by β-oxocarboxylic acids

被引：30

作者：

Banerji, B

Garcia, AC

McNeill, LA

McDonough, MA

Buck, MRG

Hewitson, KS

Oldham, NJ

Schofield, CJ

机构：

[1] Univ Oxford, Dept Chem, Oxford OX1 3TA, England

[2] Univ Oxford, Ctr Mol Sci, Chem Res Lab, Oxford OX1 3TA, England

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 43期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1039/b510707e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cyclic beta-oxocarboxylic acids inhibit factor inhibiting hypoxia-inducible factor via ligation to the active site iron.

引用

页码：5438 / 5440

页数：3

共 24 条

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