The Hfq homolog in Legionella pneumophila demonstrates regulation by LetA and RpoS and interacts with the global regulator CsrA

被引：71

作者：

McNealy, TL ^{[1
]}

Forsbach-Birk, V ^{[1
]}

Shi, CW ^{[1
]}

Marre, R ^{[1
]}

机构：

[1] Univ Ulm, Dept Med Microbiol & Hyg, D-89081 Ulm, Germany

来源：

JOURNAL OF BACTERIOLOGY | 2005年 / 187卷 / 04期

关键词：

D O I：

10.1128/JB.187.4.1527-1532.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A gene in Legionella pneumophila that has significant homology to published hfq genes demonstrated regulation by RpoS and the transcriptional regulator LetA. Additionally, Hfq has a positive effect on the presence of transcripts of the genes for CsrA and the ferric uptake regulator Fur. Mutants lacking hfq demonstrate defects in growth and pigmentation and slight defects in virulence in both amoeba and macrophage infection models. Hfq appears to play a major role in exponential-phase regulatory cascades of L. pneumophila.

引用

页码：1527 / 1532

页数：6

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