Proinflammatory cytokines in heart failure: double-edged swords

被引:175
作者
Hedayat, Mona [4 ,5 ]
Mahmoudi, Mohammad Jafar [5 ]
Rose, Noel R. [3 ]
Rezaei, Nima [1 ,2 ,4 ]
机构
[1] Univ Tehran Med Sci, Childrens Med Ctr Hosp, Tehran 14194, Iran
[2] Univ Sheffield, Dept Infect & Immun, Sch Med & Biomed Sci, Sheffield, S Yorkshire, England
[3] Johns Hopkins Univ, Johns Hopkins Ctr Autoimmune Dis Res, Baltimore, MD USA
[4] Univ Tehran Med Sci, Childrens Med Ctr, Res Grp Immunodeficiencies, Pediat Ctr Excellence, Tehran 14194, Iran
[5] Univ Tehran Med Sci, Sch Med, Dept Internal Med, Div Cardiol, Tehran 14194, Iran
关键词
Chronic heart failure; Immunopathogenesis; Cardiac myocyte hypertrophy; Contractile dysfunction; Cardiac myocyte apoptosis; Extracellular matrix remodeling; Proinflammatory cytokines; TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; LEUKEMIA INHIBITORY FACTOR; ISCHEMIA-REPERFUSION INJURY; SIGNAL-TRANSDUCTION PATHWAYS; ACUTE MYOCARDIAL-INFARCTION; HUMAN CARDIAC FIBROBLASTS; GAMMA-INDUCING FACTOR; DOXORUBICIN-INDUCED CARDIOMYOPATHY;
D O I
10.1007/s10741-010-9168-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Increased circulating and intracardiac levels of proinflammatory cytokines have been associated with chronic heart failure. Following an initial insult, the increased production of proinflammatory cytokines, including TNF-alpha, IL-6, IL-1, and IL-18, jeopardizes the surrounding tissue through propagation of the inflammatory response and direct effects on the cardiac myocyte structure and function. Cardiac myocyte hypertrophy, contractile dysfunction, cardiac myocyte apoptosis, and extracellular matrix remodeling contribute enormously to the development and progression of chronic heart failure. Despite the identification of efficacious pharmacological regimens and introduction of mechanical interventions, chronic heart failure remains among the leading causes of mortality worldwide. To introduce novel therapeutic strategies that modulate the inflammatory response in the context of the failing heart, it is of prime importance to determine the contributions of TNF-alpha, IL-6, IL-1, and IL-18 in mediating cardiac adaptive and maladaptive responses, as well as delineating their downstream intracellular signaling pathways and their potential therapeutic implications.
引用
收藏
页码:543 / 562
页数:20
相关论文
共 219 条
  • [1] Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction
    Abbate, Antonio
    Salloum, Fadi N.
    Vecile, Elena
    Das, Anindita
    Hoke, Nicholas N.
    Straino, Stefania
    Biondi-Zoccai, Giuseppe G. L.
    Houser, Jon-Erik
    Qureshi, Ian Z.
    Ownby, Evan D.
    Gustini, Edoardo
    Biasucci, Luigi M.
    Severino, Anna
    Capogrossi, Maurizio C.
    Vetrovec, George W.
    Crea, Filippo
    Baldi, Alfonso
    Kukreja, Rakesh C.
    Dobrina, Aldo
    [J]. CIRCULATION, 2008, 117 (20) : 2670 - 2683
  • [2] The role of IL-18 in innate immunity
    Akira, S
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2000, 12 (01) : 59 - 63
  • [3] Anti-tumour necrosis factor-α therapy in heart failure:: Future directions
    Balakumar, Pitchai
    Singh, Manjeet
    [J]. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2006, 99 (06) : 391 - 397
  • [4] BALLIGAND JL, 1994, J BIOL CHEM, V269, P27580
  • [5] Load-dependent and -independent regulation of proinflammatory cytokine and cytokine receptor gene expression in the adult mammalian heart
    Baumgarten, G
    Knuefermann, P
    Kalra, D
    Gao, F
    Taffet, GE
    Michael, L
    Blackshear, PJ
    Carballo, E
    Sivasubramanian, N
    Mann, DL
    [J]. CIRCULATION, 2002, 105 (18) : 2192 - 2197
  • [6] Pathophysiologically relevant concentrations of tumor necrosis factor-α promote progressive left ventricular dysfunction and remodeling in rats
    Bozkurt, B
    Kribbs, SB
    Clubb, FJ
    Michael, LH
    Didenko, VV
    Hornsby, PJ
    Seta, Y
    Oral, H
    Spinale, FG
    Mann, DL
    [J]. CIRCULATION, 1998, 97 (14) : 1382 - 1391
  • [7] Bozkurt B, 2000, ANN RHEUM DIS, V59, P90
  • [8] TNF-α and myocardial matrix metalloproteinases in heart failure:: relationship to LV remodeling
    Bradham, WS
    Moe, G
    Wendt, KA
    Scott, AA
    Konig, A
    Romanova, M
    Naik, G
    Spinale, FG
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2002, 282 (04): : H1288 - H1295
  • [9] INTERLEUKIN-1 PRETREATMENT DECREASES ISCHEMIA REPERFUSION INJURY
    BROWN, JM
    WHITE, CW
    TERADA, LS
    GROSSO, MA
    SHANLEY, PF
    MULVIN, DW
    BANERJEE, A
    WHITMAN, GJR
    HARKEN, AH
    REPINE, JE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (13) : 5026 - 5030
  • [10] Cytokines regulate matrix metalloproteinases and migration in cardiac fibroblasts
    Brown, R. Dale
    Jones, Gayle M.
    Laird, Rebecca E.
    Hudson, Paul
    Long, Carlin S.
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 362 (01) : 200 - 205