Metalloporphyrins as chemical mimics of cytochrome P-450 systems

被引：39

作者：

Chorghade, MS ^{[1
]}

Hill, DR ^{[1
]}

Lee, EC ^{[1
]}

Pariza, RJ ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,VANCOUVER,BC V6T 1Y6,CANADA

来源：

PURE AND APPLIED CHEMISTRY | 1996年 / 68卷 / 03期

关键词：

D O I：

10.1351/pac199668030753

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Certain synthetic metalloporphyrins have been shown to mimic the in vivo metabolism of some pharmaceuticals. Oxidation, hydroxylation and N-demethylation yielded synthetic metabolites. If found to be general, this lays the foundation of a predictive basis to optimize analog design of inhibitors with reduced oxidative reactivity, to determine the proclivity of drugs to form biologically active metabolites and provides a convenient methodology for their preparation.

引用

页码：753 / 756

页数：4

共 20 条

[1] AN EASY ACCESS TO POLYHALOGENATED METALLOPORPHYRINS COVALENTLY BOUND TO POLYMERIC SUPPORTS AS EFFICIENT CATALYSTS FOR HYDROCARBON OXIDATION [J].