Investigations of CHD1 function in transcription and development of Drosophila melanogaster

被引：30

作者：

McDaniel, Ivy E. ^{[1
,2
]}

Lee, Jennifer M. ^{[1
,2
]}

Berger, Matthew S. ^{[1
,2
]}

Hanagami, Cori K. ^{[1
,2
]}

Armstrong, Jennifer A. ^{[1
,2
]}

机构：

[1] Claremont Mckenna Coll, WM Keck Sci Ctr, Jonit Sci Dept, Claremont, CA 91711 USA

[2] Pitzer Coll, Claremont, CA 91711 USA

来源：

GENETICS | 2008年 / 178卷 / 01期

关键词：

D O I：

10.1534/genetics.107.079038

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In this report we describe chd1 mutant alleles and show that the CHD1 chromatin-remodeling factor is important for wing development and fertility. While CHD1 colocalizes with elongating RNA polymerase 11 (Pol II) on polytene chromosomes, elongating Pol 11 can persist on chromatin in the absence of CHD1. These results clarify the roles of chromatin remodelers in transcription and provide novel insights into CHD1 function.

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收藏

页码：583 / 587

页数：5

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