The biosynthesis of bisorbicillinoids: evidence for a biosynthetic route from bisorbicillinol to bisorbibutenolide and bisorbicillinolide

被引：18

作者：

Abe, N ^{[1
]}

Yamamoto, K ^{[1
]}

Arakawa, T ^{[1
]}

Hirota, A ^{[1
]}

机构：

[1] Univ Shizuoka, Sch Food & Nutr Sci, Shizuoka 4228526, Japan

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 01期

关键词：

D O I：

10.1039/b007181l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biosynthetic incorporation of labelled sodium acetates into bisorbicillinol in Trichoderma sp. USF-2690 suggests that bisorbicillinol is derived from 12 acetate units. Successful bioconversion of the labelled bisorbicillinols to bisorbibutenolides (bislongiquinolides) and bisorbicillinolides using the washed mycelium of the strain suggests that there are biosynthetic routes from bisorbicillinol to bisorbibutenolide and from bisorbicillinol to bisorbicillinolide.

引用

页码：23 / 24

页数：2

共 16 条

[11] 2-P
[12] Biomimetic total synthesis of bisorbicillinol, bisorbibutenolide, trichodimerol, and designed analogues of the bisorbicillinoids
Nicolaou, KC
Vassilikogiannakis, G
Simonsen, KB
Baran, PS
Zhong, YL
Vidali, VP
Pitsinos, EN
Couladouros, EA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (13) : 3071 - 3079
[13] Structural elucidation of trichotetronines: polyketides possessing a bicyclo[2.2.2]octane skeleton with a tetronic acid moiety isolated from Trichoderma sp.
Shirota, O
Pathak, V
Hossain, CF
Sekita, S
Takatori, K
Satake, M
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1997, (20): : 2961 - 2964
[14] Vertinoid polyketides from the saltwater culture of the fungus Trichoderma longibrachiatum separated from a Haliclona marine sponge
Sperry, S
Samuels, GJ
Crews, P
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (26) : 10011 - 10014
[15] BISVERTINOLS - A NEW GROUP OF DIMERIC VERTINOIDS FROM VERTICILLIUM-INTERTEXTUM
TRIFONOV, LS
HILPERT, H
FLOERSHEIM, P
DREIDING, AS
RAST, DM
SKRIVANOVA, R
HOESCH, L
[J]. TETRAHEDRON, 1986, 42 (12) : 3157 - 3179
[16] BMS-182123, a fungal metabolite that inhibits the production of TNF-alpha by macrophages and monocytes
Warr, GA
Veitch, JA
Walsh, AW
Hesler, GA
Pirnik, DM
Leet, JE
Lin, PFM
Medina, IA
McBrien, KD
Forenza, S
Clark, JM
Lam, KS
[J]. JOURNAL OF ANTIBIOTICS, 1996, 49 (03) : 234 - 240

← 1 2 →