Early events governing memory CD8+ T-cell differentiation

被引：61

作者：

Obar, Joshua J. ^{[1
]}

Lefrancois, Leo ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Immunol, Ctr Integrated Immunol & Vaccine Res, Farmington, CT 06030 USA

来源：

INTERNATIONAL IMMUNOLOGY | 2010年 / 22卷 / 08期

基金：

美国国家卫生研究院;

关键词：

CD8 T cell; CTL; differentiation; memory; DENDRITIC CELLS; IN-VIVO; INFLAMMATORY CYTOKINES; INTERLEUKIN-7; RECEPTOR; ANTIGEN PRESENTATION; SECONDARY EXPANSION; EFFECTOR PHENOTYPE; CD8-T-CELL MEMORY; CLONAL EXPANSION; CD4-T-CELL HELP;

D O I：

10.1093/intimm/dxq053

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Understanding the regulation of the CD8(+) T-cell response and how protective memory cells are generated has been intensely studied. It is now appreciated that a naive CD8(+) T cell requires at least three signals to mount an effective immune response: (i) TCR triggering, (ii) co-stimulation and (iii) inflammatory cytokines. Only recently have we begun to understand the molecular integration of those signals and how early events regulate the fate decisions of the responding CD8(+) T cells. This review will discuss the recent findings about both the extracellular and intracellular factors that regulate the destiny of responding CD8(+) T cells.

引用

收藏

页码：619 / 625

页数：7

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