Synthesis and properties of O-carboxymethyl chitosan/methoxy poly(ethylene glycol) graft copolymers

被引：15

作者：

Dong, An-Jie ^{[1
]}

Feng, Meng-Huang ^{[1
]}

Qi, Hai-Ying ^{[1
]}

Li, Shan-Shan ^{[1
]}

Deng, Lian-Dong ^{[1
]}

机构：

[1] Tianjin Univ, Sch Chem Engn & Technol, Dept Polymer Sci & Technol, Tianjin 300072, Peoples R China

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2008年 / 19卷 / 02期

关键词：

D O I：

10.1007/s10856-007-3183-6

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

O-carboxymethyl chitosan/methoxy poly(ethylene glycol) graft copolymers (OCMCS-g-MPEGs) with different degrees of substitution (DS) were synthesized by reductive N-alkylation of chitosan with poly(ethylene glycol) aldehyde. The properties of OCMCS-g-MPEGs, including the solubility, structure, hydrodynamic behaviors, isoelectric point (IEP) and interaction with water-soluble chitosan, were investigated. As a PEGylated polyampholyte, OCMCS-g-MPEGs can resolve in water over all pH range and the pH value at IEP (pH(IEP)) decreases when DS increases. The hydrodynamic behaviors of OCMCS-g-MPEGs in deionized H2O are markedly affected by DS and pH(IEP) in the experiment concentration range. The particle size of the complexes of OCMCS-g-MPEGs with water-soluble chitosan is strongly affected by the concentration of water-soluble chitosan and the pH value.

引用

收藏

页码：869 / 876

页数：8

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