Synthesis and characterization of thiomers of polyaspartamide type

被引：20

作者：

Bilicic, MB

Filipovic-Grcic, J

Martinac, A

Barbaric, M

Zorc, B

Cetina-Cizmek, B

Tudja, P

机构：

[1] Univ Zagreb, Fac Pharm & Biochem, Zagreb 10000, Croatia

[2] Res Inst Ltd, PLIVA, Zagreb 10000, Croatia

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2005年 / 291卷 / 1-2期

关键词：

thiomer; polyaspartamide; thioglycolic acid; mucoadhesion; microparticles;

D O I：

10.1016/j.ijpharm.2004.07.058

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Synthesis of poly[alpha,beta-(N-2-hydroxyethyl-DL-aspartamide)]-thioglycolic acid (PHEA-TGA) conjugate as a new polyaspartamide thiomer is described. The parent polymer PHEA is chemically modified by introducing sulphydryl-bearing compound thioglycolic acid. By varying the reaction conditions several batches of PHEA-TGA conjugates were prepared and analyzed. Tensile studies revealed that total work of adhesion of PHEA-TGA increased more than twice compared to the unmodified polymer. Microparticles prepared from the thiolated polymer preserved its bioadhesive properties. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：211 / 219

页数：9

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