Compartment-specific transcription factors orchestrate angiogenesis gradients in the embryonic brain

被引：169

作者：

Vasudevan, Anju ^{[1
,2
]}

Long, Jason E. ^{[3
]}

Crandall, James E. ^{[4
]}

Rubenstein, John L. R. ^{[3
]}

Bhide, Pradeep G. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Charlestown, MA 02129 USA

[3] Univ Calif San Francisco, Dept Psychiat, Nina Ireland Lab Dev Neurobiol, San Francisco, CA 94158 USA

[4] Univ Massachusetts, Sch Med, Eunice Kennedy Shriver Ctr Mental Retardat Inc, Waltham, MA 02452 USA

来源：

NATURE NEUROSCIENCE | 2008年 / 11卷 / 04期

关键词：

D O I：

10.1038/nn2074

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Prevailing notions of cerebral vascularization imply that blood vessels sprout passively into the brain parenchyma from pial vascular plexuses to meet metabolic needs of growing neuronal populations. Endothelial cells, building blocks of blood vessels, are thought to be homogeneous in the brain with respect to their origins, gene expression patterns and developmental mechanisms. These current notions that cerebral angiogenesis is regulated by local environmental signals contrast with current models of cell-autonomous regulation of neuronal development. Here we demonstrate that telencephalic angiogenesis in mice progresses in an orderly, ventral-to-dorsal gradient regulated by compartment-specific homeobox transcription factors. Our data offer new perspectives on intrinsic regulation of angiogenesis in the embryonic telencephalon, call for a revision of the current models of telencephalic angiogenesis and support novel roles for endothelial cells in brain development.

引用

页码：429 / 439

页数：11