The effects of vitamin D on skeletal muscle function and cellular signaling

被引：87

作者：

Dirks-Naylor, Amie J. ^{[1
]}

Lennon-Edwards, Shannon ^{[2
]}

机构：

[1] Wingate Univ, Sch Pharm, Wingate, NC 28174 USA

[2] Univ Delaware, Dept Behav Hlth & Nutr, Newark, DE 19716 USA

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2011年 / 125卷 / 3-5期

关键词：

Calcitriol; 1,25-(OH)(2)D-3; VDR; Myoblasts; Myotubes; Atrophy; PROTEIN-KINASE-C; LOWER-EXTREMITY FUNCTION; 25-HYDROXYVITAMIN D LEVELS; OPERATED CA2+ INFLUX; D-RECEPTOR; D-DEFICIENCY; CALCIUM SUPPLEMENTATION; 1-ALPHA; 25(OH)(2)-VITAMIN D-3; 1,25-DIHYDROXYVITAMIN D-3; PHYSICAL PERFORMANCE;

D O I：

10.1016/j.jsbmb.2011.03.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is thought that every cell in the body expresses the vitamin D receptor, and therefore vitamin D may play a role in health and homeostasis of every organ system, including skeletal muscle. Human, animal, and cell culture studies have collectively shown that vitamin D affects muscle strength and function. Vitamin D functions in a plethora of cellular processes in skeletal muscle including calcium homeostasis, cell proliferation, cell differentiation, fiber size, prevention of fatty degeneration, protection against insulin resistance and arachidonic acid mobilization. These processes appear to be mediated by several signaling pathways affected by vitamin D. This review aims to explore the effects of vitamin Don skeletal muscle in each model system and to delineate potential cell signaling pathways affected by vitamin D. (C) 2011 Elsevier Ltd. All rights reserved.

引用

收藏

页码：159 / 168

页数：10

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