Plasma free amino acid profile in cancer patients

被引：166

作者：

Lai, HS

Lee, JC

Lee, PH

Wang, ST

Chen, WJ

机构：

[1] Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Surg, Tainan 704, Taiwan

[2] Natl Taiwan Univ Hosp, Dept Surg, Taipei 100, Taiwan

[3] Natl Taiwan Univ, Coll Med, Taipei 10764, Taiwan

[4] Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Publ Hlth, Tainan 704, Taiwan

来源：

SEMINARS IN CANCER BIOLOGY | 2005年 / 15卷 / 04期

关键词：

plasma free amino acid; profile; cancer patients; gluconeogenesis;

D O I：

10.1016/j.semcancer.2005.04.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Redistribution or translocation of plasma free amino acids (PFAAs) to support visceral or tumor protein synthesis is an essential feature in cancer patients. An abnormal PFAA profile might be presented via the total reflection of cancer-induced protein metabolism in tumors, skeletal muscle and the liver in cancer patients. Clinical data from 13 studies have demonstrated a cancer-related PFAA profile, especially in digestive organ cancers. The PFAA profile can differ between the early and late stages of cancer. The profile is also affected by the type of cancer. Therefore, it is postulated that a detailed analysis of the PFAA profile may serve as one of the biological markers for cancer patients. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：267 / 276

页数：10

共 60 条

[21] Timing of oral glutamine on DMBA-induced tumorigenesis [J].

Kaufmann, Y ;

Luo, S ;

Johnson, A ;

Babb, K ;

Klimberg, VS .

JOURNAL OF SURGICAL RESEARCH, 2003, 111 (01) :158-165

[22]

KAWAMURA I, 1982, CANCER RES, V42, P824

[23] CANCER CACHEXIA [J].

KERN, KA ;

NORTON, JA .

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 1988, 12 (03) :286-298

[24]

KUBOTA A, 1992, CANCER, V69, P2343, DOI 10.1002/1097-0142(19920501)69:9<2343::AID-CNCR2820690924>3.0.CO

[25]

2-S

[26]

KURZER M, 1986, SURG CLIN N AM, V66, P969

[27]

Lamb DJ, 2003, J ANDROL, V24, P215

[28] TUMOR-NECROSIS-FACTOR IMPAIRS INSULIN ACTION ON PERIPHERAL GLUCOSE DISPOSAL AND HEPATIC GLUCOSE OUTPUT [J].

LANG, CH ;

DOBRESCU, C ;

BAGBY, GJ .

ENDOCRINOLOGY, 1992, 130 (01) :43-52

[29]

Lee JC, 2003, HEPATO-GASTROENTEROL, V50, P1269

[30] Induction of muscle protein degradation by a tumour factor [J].

Lorite, MJ ;

Cariuk, P ;

Tisdale, MJ .

BRITISH JOURNAL OF CANCER, 1997, 76 (08) :1035-1040

← 1 2 3 4 5 6 →