TLR signalling and activation of IRFs:: revisiting old friends from the NF-κB pathway

被引：259

作者：

Moynagh, PN ^{[1
]}

机构：

[1] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dept Pharmacol, Dublin 4, Ireland

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 09期

基金：

爱尔兰科学基金会;

关键词：

D O I：

10.1016/j.it.2005.06.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors (TLRs) are crucially important in the sensing of infectious agents. They serve to recognize pathogen-associated molecules and respond by triggering the induction of specific profiles of proteins that are tailored to the successful removal of the invading pathogens. The induction of TLR-responsive genes is mediated by the activation of transcription factors, and most interest has focussed on NF-kappa 3, a transcription factor that is universally used by all TLRs. However, there has recently been a burgeoning effort to increase our appreciation of the importance of members of the interferon-regulatory factor (IRF) family in TLR signalling. This review will discuss the most recent findings relating to the regulation of IRF activity by TLRs and will highlight the rapidly increasing complexity of TLR signalling pathways.

引用

页码：469 / 476

页数：8

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