A Short Segment of the HIV-1 gp120 V1/V2 Region Is a Major Determinant of Resistance to V1/V2 Neutralizing Antibodies

被引：69

作者：

Doria-Rose, Nicole A. ^{[1
]}

Georgiev, Ivelin ^{[1
]}

O'Dell, Sijy ^{[1
]}

Chuang, Gwo-Yu ^{[1
]}

Staupe, Ryan P. ^{[1
]}

McLellan, Jason S. ^{[1
]}

Gorman, Jason ^{[1
]}

Pancera, Marie ^{[1
]}

Bonsignori, Mattia ^{[2
,3
]}

Haynes, Barton F. ^{[2
,3
]}

Burton, Dennis R. ^{[4
,5
,6
]}

Koff, Wayne C. ^{[7
]}

Kwong, Peter D. ^{[1
]}

Mascola, John R. ^{[1
]}

机构：

[1] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

[2] Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC USA

[3] Duke Univ, Med Ctr, Durham, NC USA

[4] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA

[5] Scripps Res Inst, IAVI Neutralizing Antibody Ctr, La Jolla, CA 92037 USA

[6] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA

[7] Int AIDS Vaccine Initiat, New York, NY USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 15期

关键词：

MONOCLONAL-ANTIBODIES; ENV CLONES; PG16; PG9; BROAD; INFECTIONS; COVERAGE; REVEAL; TARGET;

D O I：

10.1128/JVI.00696-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antibody PG9 is a prototypical member of a class of V1/V2-directed antibodies that effectively neutralizes diverse strains of HIV-1. We analyzed strain-specific resistance to PG9 using sequence and structural information. For multiply resistant strains, mutations in a short segment of V1/V2 resulted in gain of sensitivity to PG9 and related V1/V2 neutralizing antibodies, suggesting both a common mechanism of HIV-1 resistance to and a common mode of recognition by this class of antibodies.

引用

页码：8319 / 8323

页数：5

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