An asymmetric synthesis (-)-epibatidine

被引：83

作者：

Trost, BM

Cook, GR

机构：

[1] Department of Chemistry, Stanford University, Stanford

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 42期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(96)01739-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Pd catalyzed desymmetrization of cis-3,6-dibenzoyloxy-2-cyclohexene and a Pd catalyzed cross-coupling constitute key reactions in a synthesis of the non-opioid analgesic (-)-epibatidine. Copyright (C) 1996 Published by Elsevier Science Ltd

引用

页码：7485 / 7488

页数：4

共 34 条

[1] TOTAL SYNTHESIS OF (+/-)-EPIBATIDINE [J].

ALBERTINI, E ;

BARCO, A ;

BENETTI, S ;

DERISI, C ;

POLLINI, GP ;

ROMAGNOLI, R ;

ZANIRATO, V .

TETRAHEDRON LETTERS, 1994, 35 (49) :9297-9300

[2]

BADIO B, 1994, MOL PHARMACOL, V45, P563

[3]

BADIO B, 1994, MED CHEM RES, V4, P440

[4] Synthesis of (+/-)-epibatidine and its analogues [J].

Bai, DG ;

Xu, R ;

Chu, GH ;

Zhu, XG .

JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (14) :4600-4606

[5] TOTAL SYNTHESIS OF EPIBATIDINE [J].

BROKA, CA .

TETRAHEDRON LETTERS, 1993, 34 (20) :3251-3254

[6]

BROKA CA, 1994, MED CHEM RES, V4, P449

[7] Chemistry of 7-azabicyclo[2.2.1]hepta-2,5-dienes, 7-azabicyclo[2.2.1]hept-2-enes, and 7-azabicyclo[2.2.1]heptanes [J].

Chen, ZM ;

Trudell, ML .

CHEMICAL REVIEWS, 1996, 96 (03) :1179-1193

[8] A TOTAL SYNTHESIS OF (PLUS-OR-MINUS)-EPIBATIDINE [J].

CLAYTON, SC ;

REGAN, AC .

TETRAHEDRON LETTERS, 1993, 34 (46) :7493-7496

[9] STEREOCONTROLLED TOTAL SYNTHESIS OF (+)-EPIBATIDINE AND (-)-EPIBATIDINE [J].

COREY, EJ ;

LOH, TP ;

ACHYUTHARAO, S ;

DALEY, DC ;

SARSHAR, S .

JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (21) :5600-5602

[10] PHARMACOLOGICAL EFFECTS OF EPIBATIDINE OPTICAL ENANTIOMERS [J].

DAMAJ, MI ;

CREASY, KR ;

GROVE, AD ;

ROSECRANS, JA ;

MARTIN, BR .

BRAIN RESEARCH, 1994, 664 (1-2) :34-40

← 1 2 3 4 →