Wound epidermis formation and function in urodele amphibian limb regeneration

被引：69

作者：

Campbell, L. J. ^{[1
]}

Crews, C. M. ^{[1
,2
,3
]}

机构：

[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

[2] Yale Univ, Dept Pharmacol, New Haven, CT 06520 USA

[3] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 01期

关键词：

limb regeneration; cell migration; wound healing; wound epidermis; positional information; blastema; dedifferentiation;

D O I：

10.1007/s00018-007-7433-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Upon amputation of the urodele limb, the epidermal cells surrounding the amputation plane migrate to heal the wound. The resulting wound epidermis (WE) induces the regeneration process, resulting in blastema formation, cell division, and ultimately repatterning into a new limb. Despite its central role in the initiation of limb regeneration, little is known about how the WE forms. Here we discuss various models of WE formation and the experimental data in support of each.

引用

页码：73 / 79

页数：7

共 57 条

[41] SCANNING ELECTRON-MICROSCOPY OF EPIDERMAL-CELL MIGRATION IN WOUND-HEALING DURING LIMB REGENERATION IN ADULT NEWT, NOTOPHTHALMUS-VIRIDESCENS
REPESH, LA
OBERPRILLER, JC
[J]. AMERICAN JOURNAL OF ANATOMY, 1978, 151 (04): : 539 - 555
[42] Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb
RodriguezEsteban, C
Schwabe, JWR
DeLaPena, J
Foys, B
Eshelman, B
Belmonte, JCI
[J]. NATURE, 1997, 386 (6623) : 360 - 366
[43] Shimizu-Nishikawa K, 1999, DEV GROWTH DIFFER, V41, P731
[44] THE INVASION OF THE EPIDERMIS OF THE REGENERATING FORELIMB OF THE URODELE, TRITURUS, BY NERVE FIBERS
SINGER, M
[J]. JOURNAL OF EXPERIMENTAL ZOOLOGY, 1949, 111 (02): : 189 - &
[45] SINGER M, 1961, GROWTH LIVING SYSTEM, P277
[46] SINGER MARCUS, 1952, QUART REV BIOL, V27, P169, DOI 10.1086/398873
[47] THE WOUND EPITHELIUM OF REGENERATING LIMBS OF PLEURODELES-WALTL AND NOTOPHTHALMUS-VIRIDESCENS - STUDIES WITH MABS WE3 AND WE4, PHALLOIDIN, AND DNASE-1
TASSAVA, RA
CASTILLA, M
ARSANTO, JP
THOUVENY, Y
[J]. JOURNAL OF EXPERIMENTAL ZOOLOGY, 1993, 267 (02): : 180 - 187
[48] REGENERATIVE RESPONSES IN LARVAL AXOLOTL LIMBS WITH SKIN-GRAFTS OVER THE AMPUTATION SURFACE
TASSAVA, RA
GARLING, DJ
[J]. JOURNAL OF EXPERIMENTAL ZOOLOGY, 1979, 208 (01): : 97 - +
[49] REGENERATE EPITHELIUM AND SKIN GLANDS OF THE ADULT NEWT REACT TO THE SAME MONOCLONAL-ANTIBODY
TASSAVA, RA
JOHNSONWINT, B
GROSS, J
[J]. JOURNAL OF EXPERIMENTAL ZOOLOGY, 1986, 239 (02): : 229 - 240
[50] THE EFFECT OF APICAL CAP REMOVAL ON LIMB REGENERATION IN AMBLYSTOMA LARVAE
THORNTON, CS
[J]. JOURNAL OF EXPERIMENTAL ZOOLOGY, 1957, 134 (02): : 357 - 377

← 1 2 3 4 5 6 →