Expression of BLT1 leukotriene B4 receptor on the dorsal root ganglion neurons in mice

被引：55

作者：

Andoh, T

Kuraishia, Y

机构：

[1] Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Appl Pharmacol, Toyama 9300194, Japan

[2] Toyama Med & Pharmaceut Univ, 21st Century COE Program, Toyama 9300194, Japan

来源：

MOLECULAR BRAIN RESEARCH | 2005年 / 137卷 / 1-2期

关键词：

BLT1; receptor; leukotriene B-4; dorsal root ganglion neuron; intracellular Ca2+;

D O I：

10.1016/j.molbrainres.2005.02.029

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated using mice whether dorsal root ganglion (DRG) neurons express leukotriene 134 receptors. BLT1, but not BLT2, receptor mRNA was expressed in the DRG. Leukotriene B-4 increased intracellular Ca2+ concentration in cultured DRG neurons, which was inhibited by leukotriene B-4 antagonist. Many BLT1-immunoreactive neurons were small in size and positive for TRPV1. BLT1-immunoreactive fibers are present in the skin. The results suggest the expression of functional BLT1 receptors in the sensory neurons. (c) 2005 Elsevier B.V. All rights reserved.

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收藏

页码：263 / 266

页数：4

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