Sequence analysis and genetic classification of tick-borne encephalitis viruses from Europe and Asia

被引：306

作者：

Ecker, M ^{[1
]}

Allison, SL ^{[1
]}

Meixner, T ^{[1
]}

Heinz, FX ^{[1
]}

机构：

[1] Univ Vienna, Inst Virol, A-1095 Vienna, Austria

来源：

JOURNAL OF GENERAL VIROLOGY | 1999年 / 80卷

关键词：

D O I：

10.1099/0022-1317-80-1-179

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The epidemiology of tick-borne encephalitis virus was investigated by comparative sequence analysis of virus strains isolated in endemic areas of Europe and Asia. Phylogenetic relationships were determined from the nucleotide and amino acid sequences of the major envelope (E) protein of 16 newly sequenced strains and nine previously published sequences. Three genetic lineages could be clearly distinguished, corresponding to a European, a Far Eastern and a Siberian subtype. Amino acids characteristic for each of the subtypes ('signature' amino acids) were identified and their location in the atomic structure of protein E was determined. The degree of variation between strains within subtypes was low and exhibited a maximum of only 2.2% at the amino acid level. A maximum difference of 5.6% was found between the three subtypes, which is in the range of variation reported for other flaviviruses.

引用

页码：179 / 185

页数：7

共 47 条

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