Diastereomeric quinolinone alkaloids from the marine-derived fungus Penicillium janczewskii

被引：104

作者：

He, J

Lion, U

Sattler, I

Gollmick, FA

Grabley, S

Cai, JM

Meiners, M

Schünke, H

Schaumann, K

Dechert, U

Krohn, M

机构：

[1] Hans Knoell Inst, Leibniz Inst Nat Prod Res & Infect Biol, D-07745 Jena, Germany

[2] FHO, D-26723 Emden, Germany

[3] Biotechnol Res & Informat Network AG, D-64673 Zwingenberg, Germany

[4] Alfred Wegener Inst Polar & Marine Res, D-27570 Bremerhaven, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 09期

关键词：

D O I：

10.1021/np058018g

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

From Penicillium janczewskii, obtained from a marine sample, two new diastereomeric quinolinones, 3S*,4R*-dihydroxy-4-(4 '-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (1) and 3R*,4R*-dihydroxy-4-(4 ' methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (2), were identified, along with two known alkaloids, peniprequinolone (3) and 3-methoxy-4-hydroxy-4-(4 '-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (4). Cytotoxicity testing on eight tumor cell lines revealed a moderate specificity of 2 on SKOV-3 cells.

引用

页码：1397 / 1399

页数：3

共 11 条

[1] Research achievement award-D. John Faulkner [J].